Oxidative Bisulfite Sequencing (oxBS-Seq) A Brilliant Advance for Epigenetics
There is exciting news regarding a new method to detect 5-hmC quantitatively at high resolution – using any sequencing platform. The new method, termed oxidative bisulfite sequencing (oxBS-Seq) , was...
View Article5hmC Regulates Cellular Differentiation
What was once surprising is now established. DNA methylation is not static after imprinting. All genes are not silenced “forever” through DNA methylation. But how does this dynamic and reversible...
View ArticleIntroducing Aba-seq for Enzyme Based High-Res Mapping of Mammalian...
New England Biolabs is well known for its extensive in house research programs – churning out numerous publications every year. The role of hydroxymethylation as a possible cancer biomarker is a topic...
View ArticleTet1 Enzyme Based Enrichment Method for Methylome Sequencing: TamC-Seq
Here’s another great advance in methylome sequencing. You all know about bisulfite sequencing, the “gold standard” method. Unfortunately it’s expensive. It also requires a lot of sample, due to DNA...
View ArticleReading the Effect of Tea Leaves…and Beating Genetic Fatalism in Breast Cancer
The recent news about Angelina Jolie getting a prophylactic double mastectomy is both sad and encouraging. Women, and their physicians, are becoming more aware of individual breast cancer risk. They...
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